ISO 13485 Section 7.5.5 + FDA 21 CFR 820.150 + EU MDR

GDP & Cold Chain Toolkit

GDP procedure, cold chain validation protocol, temperature excursion investigation, distribution traceability, carrier qualification, and storage area monitoring — complete distribution controls for temperature-sensitive medical devices.

6 documents · Instant download · 30-day guarantee

What You Get

DOC 01

Good Distribution Practice Procedure (GDP) for Medical Devices

Complete GDP procedure for medical device distribution operations. Covers receiving and storage controls, shipment preparation and packaging, carrier qualification, distribution records, returned goods handling, and the temperature-sensitive product handling requirements. Aligned with ISO 13485 Section 7.5.5, FDA 21 CFR 820.150, and EU MDR distribution requirements for economic operators.

DOC 02

Cold Chain Validation Protocol Template

Validation protocol for establishing and qualifying a cold chain distribution system for temperature-sensitive medical devices. Covers temperature mapping study design, data logger placement rationale, acceptance criteria for temperature excursion limits, worst-case shipping lane selection, and the validation summary report that demonstrates the cold chain maintains product quality throughout the distribution cycle.

DOC 03

Temperature Excursion Investigation and Disposition Template

Structured investigation template for temperature excursion events during storage or shipment. Covers excursion detection and notification, excursion severity classification, product impact assessment methodology, disposition decision documentation (use, quarantine, discard), and the CAPA trigger criteria for excursions that indicate systemic cold chain failures requiring corrective action.

DOC 04

Distribution Control and Lot Traceability Procedure

Complete distribution control procedure covering lot and serial number traceability throughout the distribution chain. Covers distributor authorization records, distribution database requirements, UDI traceability linkage, customer hold and recall notification capability testing, and the two-generation-forward, one-generation-back traceability standard FDA expects for recall effectiveness. Aligned with 21 CFR 820.160.

DOC 05

Carrier and Logistics Provider Qualification Checklist

Qualification checklist for third-party carriers and logistics providers handling temperature-sensitive medical devices. Covers GDP compliance verification, temperature monitoring capability assessment, cold chain breach notification protocol, chain of custody documentation, and the quality agreement provisions that define carrier responsibilities for temperature excursion reporting and product integrity preservation.

DOC 06

Storage Area Temperature Mapping and Monitoring Plan

Protocol for temperature mapping a storage area and establishing an ongoing temperature monitoring program. Covers mapping study design, sensor placement methodology, acceptance criteria by storage classification, alarm threshold setting, out-of-specification response procedure, and the monitoring equipment calibration and maintenance schedule. Pre-formatted as a controlled QMS document.

FAQ

Is GDP required for all medical devices?

GDP documentation is required for all medical devices under ISO 13485 Section 7.5.5 (preservation of product) and FDA 21 CFR 820.150 (storage). Temperature-sensitive devices have additional validation requirements for cold chain qualification.

What traceability is required for medical device distribution?

FDA 21 CFR 820.160 requires distribution records that enable two-generation-forward, one-generation-back traceability to support recall effectiveness. EU MDR requires economic operators to maintain distribution records for a minimum of 10 years.

What format are the documents?

All documents are editable Word and Excel templates ready for direct use in your QMS.

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For informational purposes only. Not legal or regulatory advice. Legal